Phenylalanine: Danger And Its Health Benefits

Phenylalanine danger isn’t something that is so common. And that’s because most people just consume enough from their diet. While people that take supplements take it in moderation. But phenylalanine danger could become imminent in people with PKU and people that are pregnant.

pregnant woman

You would agree that supplements are a good way of getting the nutrients you can’t get from your food. Supplements are great and doctors advise we take some certain supplements regularly. But the truth is that taking supplements in excess could pose harm. For instance, taking excess phenylalanine could lead to serious medical conditions. That’s why today we will be having a look at various conditions associated with phenylalanine danger.

Phenylalanine is one of the essential amino acids. This amino acid is required by the body because the body can’t produce it. Phenylalanine is one of the amino acids required for the production of proteins. And also for other body functions. Phenylalanine can be found easily in food products. And we will have a look at these foods later. The good thing about this amino acid is that it’s available as a supplement. But this could also pose danger. If taken in excess it poses phenylalanine danger that comes with certain signs and symptoms.

What is Phenylalanine?

So phenylalanine is one of the amino acids that our body uses. Phenylalanine serves as one of the building blocks of protein formed in the body. It’s one of the nine essential amino acids. Which makes it very important.

Phenylalanine actually occurs in two different forms. We have D and L phenylalanine. These two forms are very similar in nature. But they slightly differ in their molecular structure.

Here’s another difference between these two forms. L-phenylalanine is the type found in foods. And it’s used for the production of proteins in the body. But on the other hand, D-phenylalanine is the synthesized type. It’s mostly used in medical applications.

Phenylalanine has been found out to produce other substances in the body. And these substances aid in the transmission of some signals in the body.

Also, phenylalanine over time has been found to have an effect on certain medical conditions. That’s why phenylalanine supplements are being given to patients with depression and even skin disorders. There are other conditions that phenylalanine is effective for. We will be having a look at them later.

Phenylalanine also has an effect on the production of certain hormones in the body. It is involved in the production of tyrosine, epinephrine, and norepinephrine. Any problem with the production of any of these could lead to a serious health problem.

Benefits of Phenylalanine

So many people have carried out different research and studies to find out the benefits of this amino acid. And it has been found out that phenylalanine is indeed great for treating certain medical conditions.


One research was about the effect of phenylalanine in treating vitiligo. What is vitiligo? Vitiligo is a skin disorder that causes the loss of skin color and also blotching. Vitiligo is actually characterized as an unpredictable condition. There is the presence of white patches in this condition. So the research found out that when phenylalanine is combined with some other factors such as UV light it becomes very effective. At the same time, they also found out that topical creams that contained this amino acid were very effective.

Pain relief

So there were studies done to check the effect of phenylalanine on pain. They wanted to check if it would help extend or even increase the effect of certain painkillers. The reason for this research is because phenylalanine and other amino acids are involved in making chemical messengers. So there’s a larger probability they would help reduce pain. They found out that D-phenylalanine could be very effective in contributing to pain relief. But the results though were mixed. So it’s not definite.


This is another condition that studies have shown phenylalanine helps out with. ADHD is a condition that is usually diagnosed in children. It’s associated with having difficulty paying attention and also being impulsive. The studies showed that children with this condition had lower levels of aromatic amino acids. And one aromatic amino acid is phenylalanine. But after doing the studies on a very large scale children with ADHD did not lack this amino acid. This is why it’s inconclusive whether phenylalanine could be effective for this condition.


Phenylalanine is actually used in producing other neurotransmitters in the body. One of which is dopamine. And a lack of dopamine has actually been linked to depression. So there’s a large probability that if phenylalanine level in the body is increased there would be lesser signs of depression. In one study they gave patients DL-phenylalanine. And they found out that patients who received this were a bit better. But it has not been confirmed that phenylalanine is indeed a good treatment method for depression.

Alcohol withdrawal

A small study actually looked at the effect of phenylalanine on alcohol withdrawal. A supplement of D-phenylalanine, L-5-hydroxytryptophan, and L-glutamine was added to the diet of patients. After some days it was proven that this combination actually helps alleviate withdrawal symptoms of the patient. One thing though is that the specific role of phenylalanine in this research was not found. It’s just known it’s good as a combination therapy for patients going through alcohol detoxification. With more studies may be the exact role of phenylalanine in alcohol withdrawal would be found out.

All these are some of the benefits phenylalanine could offer. The thing though is that some of these still need more studies and research. So maybe in some years to come, phenylalanine could become an effective form of treatment for these conditions.

Phenylalanine Danger

So this is a very big question. Can an amino acid that has so many benefits be dangerous? Well, the answer to that is yes. And it’s because of phenylalanine danger. 

Phenylalanine danger is the danger that comes with taking excess phenylalanine. This danger could also be a result of the condition of the patient. For instance, phenylalanine can be very dangerous for people with phenylketonuria (PKU). That’s because people with PKU have phenylalanine level about 400 times the normal amount in a person.

In terms of taking phenylalanine in excess, of course, that does not have to do with the foods we eat. You can’t get phenylalanine danger from that. In fact, even with supplements, you would have to take more than 100mg per kg to see any effects.

Also, taking too much phenylalanine supplements during pregnancy can be bad for the baby. That’s because it increases the chances of the baby having birth defects. The risk that it would be a facial defect is high around 10-14 weeks of gestation. For the nervous system and growth, it’s about 3-18 weeks. So if you don’t have PKU as a mother just consume enough phenylalanine in your regular diet. That would be enough to prevent phenylalanine danger.

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